Frequently Asked Questions
How are peptides synthesized?
Peptides are created by linking amino acids with peptide bonds. This bond forms when one amino acid’s amino group connects with another’s carboxyl group, releasing water.
In the lab, peptides are usually made through solid-phase peptide synthesis:
- Start: The first amino acid attaches to a solid support with a protected amino group.
- Add Amino Acids: The protecting group is removed, and the next amino acid is added to form a bond.
- Repeat: This process continues until the desired peptide is complete.
- Finish: The final peptide is detached from the solid support and any remaining protecting groups are removed.
This method allows scientists to create peptides with specific amino acid sequences for research and development.
Do your peptides include mannitol?
Yes, all our peptides contain trace amounts of mannitol. Mannitol is a sugar alcohol that helps:
- Stability: Prevents peptide aggregation and maintains structure.
- Solubility: Enhances peptide solubility in water or saline.
- Moisture Protection: Absorbs moisture to protect peptides from degradation.
- Handling: Improves the flow properties of peptide powders for easy processing.
Mannitol ensures you can see the peptide product in the vial.
What are the best practices for handling and storing peptides?
Peptides absorb moisture, so let them warm to room temperature before opening. Follow these steps for handling:
- Weigh Quickly: In a clean environment, weigh only what you need.
- Reseal Tightly: Close the container after use.
- Store Properly: Keep unused peptides at -20°C or lower in a sealed container with a desiccant.
Proper storage reduces bacterial degradation and oxidation, extending shelf life. When dissolving peptides, use recommended solvents and sonication if needed. Sterilized water is preferred, but buffers can be used based on peptide properties.
Important: Peptides in solution are less stable than in freeze-dried form. If storing in solution, keep at -20°C with sterile buffers at pH 5-6.
Which payment methods are accepted?
We accept:
- Bank transfers
- Card payments (Visa, MasterCard, and Amex)
Choose your payment method at checkout.
What shipping options are available?
For UK Customers:
- Royal Mail 24: £5 for reliable delivery.
- DPD UK: £5.20 for trusted delivery services.
For International Customers:
- We use the most efficient option, either Royal Mail or DPD International. Track your shipment and arrange for a safe delivery location if needed.
What should I do if there's an issue with my delivery?
Tracking Your Parcel
For DPD deliveries, you can download the DPD app for real-time updates. For Royal Mail shipments, visit their tracking website and enter your tracking number for the latest information.
Our Parcel Follow-up Policy
We understand the importance of timely deliveries. Please allow up to seven days for your parcel to arrive before contacting us. This helps accommodate any minor shipping delays.
International Deliveries and Customs
International deliveries may be held in customs, causing delays beyond our control. If customs request additional documents, we are here to assist, but resolution time depends on customs authorities.
How are your peptides shipped?
Shipping Process
Our peptides are shipped in their lyophilized (freeze-dried) state to ensure stability. We package them carefully to protect against environmental factors.
Protection from Sunlight
Our packaging shields peptides from direct sunlight, preserving their condition during transit.
Post-Delivery Handling and Storage
Upon receipt, handle peptides properly. Once reconstituted, store them in the refrigerator to maintain quality and effectiveness.
Need Further Assistance?
If you have questions about our peptides, shipment, or handling, contact us. We are here to support you.
What happens after I make a payment?
Thank you for your order and payment. We do not individually confirm payments to avoid processing delays. Our dispatch team will process your order promptly once the payment is registered. You will receive an email confirmation and tracking information later today. Thank you for your understanding and support.
Do you offer blended peptides?
We do not offer blended peptides like ipamorelin and CJC MOD GRF. Blends often have inappropriate ratios for most research applications, making exact microgram usage difficult to determine. We recommend purchasing peptides separately to ensure accurate and reliable research results. For example, you can mix 100mcg of Peptide A and 100mcg of Peptide B in the same syringe. This ensures precise dosage and integrity in your research.
Combining two peptides into a single vial is not necessarily cheaper. Purchasing separately maintains accuracy and effectiveness.
Can I get a certificate of analysis (CoA) for your products?
Yes, we provide a Certificate of Analysis (CoA) for all our products. Visit the product page on our website and select the ‘Certificate of Analysis’ option to download the PDF. All CoA documents are for informational purposes and must not be modified or edited.
What impurities are commonly found in peptide synthesis?
In purified peptides, the main impurities are deletions and truncations of the original sequence. These arise due to factors like steric hindrance and the secondary structure of the growing peptide chain, which can hinder the efficiency of the incoming amino acid’s reaction.
- Truncation: A shorter C-terminal fragment of the peptide than the original sequence.
- Deletion: The original sequence is missing one or more amino acids at any position within the peptide.
Specific reagents used during the cleavage of the peptide from the solid phase may also be contaminants. However, these are typically volatile, evaporate during freeze-drying, and are removed during purification.
How does peptide purity differ from peptide yield?
Peptide Purity: Assessed using analytical methods like reverse-phase high-performance liquid chromatography (RP-HPLC) and mass spectrometry (MS). This analysis provides a percentage indicating the portion of the sample detected via UV absorbance of specific chemical groups (in HPLC) or charged species (in MS). It does not account for the presence of water and salts in the sample.
Peptide Yield: Determined through Amino Acid Analysis (AAA), which calculates the actual amount of peptide in the sample. This method allows for the calculation of the moles of peptide present. The difference between the weighed mass (before AAA) and the measured result (after AAA) is generally due to water and salts in the sample.
Why don't your products contain LCPS (Lipopolysaccharides)?
Lipopolysaccharides (LCPS), or endotoxins, are large molecules in the outer membrane of Gram-negative bacteria such as E. coli. These contaminants can trigger strong immune responses, making their presence in peptide products highly undesirable, especially for research and therapeutic applications.
At our company, we ensure that our products do not contain LCPS by exclusively using synthetic peptides. Unlike methods that involve bacterial expression systems, such as E. coli, to produce peptides, our synthetic approach eliminates the risk of LCPS contamination.
By employing advanced chemical synthesis techniques, we can precisely construct peptides in a controlled environment, ensuring high purity and consistency. This method guarantees the absence of bacterial contaminants like LCPS and allows us to avoid other potential impurities associated with biological production systems.
In summary, our commitment to using synthetic peptides ensures that our products are free from LCPS and other bacterial contaminants, providing you with safer and more reliable peptide solutions for your research and therapeutic needs.